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ASTHMA

After 3 months of combining chiropractic SMT (spinal manipulative therapy) with optimal medical management for pediatric asthma, the children rated their quality of life substantially higher and their asthma severity substantially lower. These improvements were maintained at the 1-year follow-up assessment. There were no important changes in lung function or hyperresponsiveness at any time.
               Bronfort G, Evans RL, Kubic P, Filkin P.  Chronic pediatric asthma and chiropractic spinal manipulation: A prospective clinical series and randomized clinical pilot study.  J Manipulative Physiol Ther 2001; 24(6): 369-77

Significantly lower quality of life impairment rating scores were reported for 90.1% of children after 60 days of chiropractic care. During this same time period the average number of asthma attacks decreased an average of 44.9%, and asthma medication usage was decreased an average of 66.5%. 
               Graham RL; Pistolese RA. An impairment rating analysis of asthmatic children under chiropractic care. J Vertebral Subluxation Res 1997; 1(4): 41-8 / Cinahl ID:1998069399

Among parents of asthmatic children who had received chiropractic treatment, 92% considered this treatment beneficial. Alternative treatment was more frequent among children from the higher social classes. A tendency was observed towards less satisfaction with medical treatment, information and general guidance concerning the illness among families who sought alternative treatment.
               Vange B; Contact between preschool children with chronic diseases and the authorized health services and forms of alternative therapy. Ugeskr Laeger 1989; 151(28):1815-8 / Medline ID: 89369847

Patients with juvenile onset asthma are most likely obtain a perceived benefit from chiropractic spinal adjustments. Patients reported improvement after an average of five treatments over a one-month period of time.  
               Nilsson N, Christainson B; Prognostic factors in bronchial asthma in chiropractic practice. J Aust Chiropr Assoc. 1988; 18(3):85-7 / Mantis ID: 7210

While under chiropractic care 6 of 15 patient's studied elected to voluntarily reduce their daily dose of medication. An additional patient stopped using medication all together. This represents a 46.67% decrease in the need for medication while under chiropractic care. However, the authors failed to recognize less need for medication as an improvement in condition.
               Jamison JR, Leskovic K, Lepore S, Hannon P; Asthma in a chiropractic clinic: a pilot study. J Aust Chiropr Assoc. 1986; 16(4):137-43 / Mantis ID: 12794

A study was conducted on 58 patients to determine whether the upper cervical knee chest adjustment, influenced pulmonary function.  FEV-1 and FVC were measured before care and two weeks after care on a computerized auto-spiro spirometer. Analysis of the spirometry measurements revealed predictable statistically significant changes in FVC and FEV-1.  Of the 58 patients, 57% of the subject population were considered to have "abnormal" lung function before care. The abnormal group showed the greatest increases in FVC and FEV-1 over the two-week study.  Forty-two percent of the abnormal patient population actually tested within normal limits after the two-week study. The "normal" subject population also showed predictable increases in tendency to return to normal was clearly observed in just two weeks under specific chiropractic care.
               Kessinger, R. Specific upper cervical chiropractic care and lung function.  CRJ 1997; 4(1): 27 / Mantis ID: 38010

76.5% of patients with bronchial asthma said they benefited from chiropractic treatment. Peak flow rate and vital capacity increased after the third treatment.
               Hviid C; A comparison of the effect of chiropractic treatment on respiratory function in patients with respiratory distress symptoms and patients without. Bull Eur Chiro Union 1978; 26: 17-34 / Mantis ID: 3222

Lung volumes were measured in 50 patients presenting with complaints. Post treatment forced vital capacity (FVC) was found to be greater than pre-treatment. Post-treatment forced expiratory volume in one second (FEV-1) was found to be greater than pre-treatment FEV-1.
               Masarsky C; Weber M; Chiropractic and lung volumes--A retrospective study. ACA J of Chiropr 1986; 23(9): 65-8 / Mantis ID: 13721

FVC and FEV-1 both improved significantly in asthmatic patients under chiropractic care.
               Kessinger R; Changes in pulmonary function associated with upper cervical specific chiropractic care. J Vertebral Subluxation Res 1997; 1(3): 43-9 / Mantis ID: 38608

Over the course of the study, non-specific bronchial hyperreactivity (n-BR) improved by 36% (P = 0.01) and patient-rated asthma severity decreased by 34% (P = 0.0002) compared with the baseline values.
               Nielsen NH, Bronfort G, Bendix T, Madsen F, Weeke B. Chronic asthma and chiropractic spinal manipulation: a randomized clinical trial.Clin Exp Allergy 1995; 25 (1): 80-88 / Medline ID: 95245893

Mobility and kyphosis of the thoracic spine were correlated with lung function in 185 men and 87 women not suffering from respiratory disease. Mobility of the thoracic spine was shown to directly effect respiratory function.
               Mellin G; Harjula R; Lung function in relation to thoracic spinal mobility and kyphosis. Scand J Rehabil Med 1987; 19(2):89-92 / Medline ID: 87291944

Results of epidemiological studies provide strong evidence that exposure of children to environmental tobacco smoke is associated with increased rates of lower respiratory illness, asthma, middle ear effusion, and sudden infant death syndrome. Exposure during childhood may also be associated with development of cancer during adulthood.
               Environmental tobacco smoke: a hazard to children. American Academy of Pediatrics Committee on Environmental Health. Pediatrics 1997; 99(4):639-42 / Medline ID: 97247193

During a 1-month follow-up period, the tobacco-smoking group (defined as having at least 1 smoker in the home) had a significantly greater number of symptomatic days than the nonsmoking group. Of the children in the nonsmoking group, 82% had less than 1 symptomatic day per week compared with 27% in the tobacco-smoking group.
               Abulhosn RS, Morray BH, Llewellyn CE, Redding GJ, Passive smoke exposure impairs recovery after hospitalization for acute asthma. Arch Pediatr Adolesc Med 1997; 151(2):135-9 / Medline ID: 97194429

In patients with mild asthma, there is no obvious advantage or major disadvantage to the regular use of inhaled albuterol.
               Drazen JM, Israel E, Boushey HA, Chinchilli VM, Fahy JV, Fish JE, Lazarus SC, Lemanske RF, Martin RJ, Peters SP, Sorkness C, Szefler SJ. Comparison of regularly scheduled with as-needed use of albuterol in mild asthma. N Engl J Med 1996; 335:841-7 / Medline ID: 96357201

Regular treatment of patients with mild asthma with salmeterol leads to tolerance to its protective effects against a bronchoconstrictor stimulus, in this case inhaled methacholine, despite well-maintained bronchodilation. This finding raises concern about the effectiveness of prolonged therapy with long-acting beta 2-adrenoceptor agonists in asthma. 
               Cheung D; Timmers MC; Zwinderman AH; Bel EH; Dijkman JH; Sterk PJ.   Long-term effects of a long-acting beta 2-adrenoceptor agonist, salmeterol, on airway hyperresponsiveness in patients with mild asthma.  N Engl J Med 1992;   327(17):1198-203 / Medline ID: 93024705

Immunotherapy for treatment of asthma, as studied over a 30 month period in 121 children, showed that immunotherapy was of no benefit.
               Adkinson NF Jr, Eggleston PA, Eney D, Goldstein EO, Schuberth KC, Bacon JR, Hamilton RG, Weiss ME, Arshad H, Meinert CL, Tonascia J, Wheeler B; A controlled trial of immunotherapy for asthma in allergic children. N Engl J Med 1997; 336(5):324-31 / Medline ID: 97156224

An increased risk of death, or near death, from asthma has been associated with the regular use of Beta 2 Agonist bronchodilator's fenoterol and albuterol.
               Spitzer WO, Suissa S, Ernst P, Horwitz RI, Habbick B, Cockcroft D, Boivin JF, McNutt M, Buist AS, Rebuck AS. The use of beta-agonists and the risk of death and near death from asthma. N Engl J Med 1992; 326:501-6 / Medline ID: 92123306

Regular use of inhaled (beta)2-agonist may also result in a partial loss of the bronchoprotective effect afforded by these agents against exercise-induced bronchoconstriction.
               Inman MD, O'Byrne PM. The effect of regular inhaled albuterol on exercise-induced bronchoconstriction. Am J Respir Crit Care Med 1996; 153:65-9 / Medline ID: 96134199

In 70% of patients studied control was better during placebo treatment with bronchodilator for symptom relief. Regular inhalation of a beta agonist agent was associated with deterioration of asthma control in the majority of subjects. The trends to use of regular, higher doses or longer-acting inhaled beta-sympathomimetic treatment may be an important causal factor in the worldwide increase in morbidity from asthma.
               Sears MR, Taylor DR, Print CG, Lake DC, Li QQ, Flannery EM, Yates DM, Lucas MK, Herbison GP. Regular inhaled beta-agonist treatment in bronchial asthma. Lancet 1990; 336:1391-6 / Medline ID: 91061542

In two studies, it has been reported that the scheduled use of inhaled (beta)2-agonist was associated with more exacerbation's of asthma, and with a decline in lung function.
               Sears MR, Taylor DR, Print CG, Lake DC, Li QQ, Flannery EM, Yates DM, Lucas MK, Herbison GP. Regular inhaled beta-agonist treatment in bronchial asthma. Lancet 1990; 336:1391-6 / Medline ID: 91061542
               van Schayck CP, Dompeling E, van Herwaarden CL, Folgering H, Verbeek AL, van der Hoogen HJ, van Weel C. Bronchodilator treatment in moderate asthma or chronic bronchitis: continuous or on demand? A randomised controlled study. BMJ 1991; 303:1426-31 / Medline ID: 92127201

Although corticosteroids are commonly prescribed in the treatment of bronchiolitis, there is no evidence on the efficacy of these drugs in this disorder.  There were no differences between the dexamethasone and placebo-treated infants.   Our findings do not support the use of dexamethasone in the treatment of bronchiolitis in infants.
               Roosevelt G; Sheehan K; Grupp-Phelan J; Tanz RR; Listernick R. Dexamethasone in bronchiolitis: a randomised controlled trial.  Lancet 1996;348(9023):292-5 / Medline ID: 96312261

Oral dexamethasone therapy does not affect the clinical course of children hospitalized with bronchiolitis and therefore cannot be recommended in this clinical situation.
               Klassen TP; Sutcliffe T; Watters LK; Wells GA; Allen UD; Li MM.   Dexamethasone in salbutamol-treated inpatients with acute bronchiolitis: a randomized, controlled trial. J Pediatr 1997;130(2):191-6 / Medline ID: 97194681

Several asthma and allergy researchers have found that asthma and allergies were more common in children that received pertussis vaccine than in those that were not immunized.  Similar results have been suggested by others.
               Odent MR, Culpin EE, Kimmel T. Pertussis vaccination and asthma: is there a link? JAMA 1994; 272(8): 592-3./ Medline ID: 94335157
               Kemp T, Pearce N, Fitzharris P, Crane J, Fergusson D, St. George I, Wickens K, Beasley R. Is infant immunization a risk factor for childhood asthma or allergy. Epidemiology 1997; 8(6): 678-80 / Medline ID: 9800555


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